Alexander Cigan

Ph.D. Candidate
212-854-4259

Research Interests

  • Musculoskeletal tissue engineering
  • Nutrient transport
  • Cartilage biomechanics

Education

  • B.S. Tulane University, Biomedical Engineering, 2009
  • M.S. Tulane University, Biomedical Engineering, 2010
  • M.Phil. Columbia University, 2013

Hailing from Portland, Oregon, Alexander received both his BS and MS in Biomedical Engineering from Tulane University and is now a Ph.D. candidate in Dr. Gerard Ateshian's Musculoskeletal Biomechanics Laboratory.  His research interests include cartilage tissue engineering, cartilage biomechanics, nutrient transport and extracellular matrix synthesis within engineered cartilage, and techniques for engineering large chondrocyte-agarose constructs to treat cartilage defects found in osteoarthritic joints.

When outside of lab, Alexander tests full joints in bending and torsion with Brazilian jiu-jitsu, and cultures large yeast-beer constructs.

Full-Length Papers

Albro, M. B., Nims, R. J., Durney, K. M., Cigan, A. D., Shim, J. J., Vunjak-Novakovic, G., Hung, C. T., Ateshian, G. A. , 2016. Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-&beta. Biomaterials 77:173-185 PubMed.

Nims, R. J., Cigan, A. D., Albro, M. B., Vunjak-Novakovic, G., Hung, C. T., Ateshian, G. A., 2015. Matrix production in large engineered cartilage constructs is enhanced by nutrient channels and excess media supply. Tissue Eng Part C 21(7):747-57 PubMed.

Cigan, A. D., Nims, R. J., Albro, M. B., Vunjak-Novakovic, G., Hung, C. T., Ateshian, G. A., 2014. Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs.  J Biomech 47(16):3847-54 PubMed.

O’Connell, G. D., Nims, R. J., Green, J., Cigan, A. D., Ateshian, G. A., Hung, C. T., 2014. Time- and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage.  Eur Cell Mater 27:312-20 PubMed.

Nims, R. J., Cigan, A. D., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels. J Biomech 47(9):2165-72 PubMed.

Cigan, A. D., Nims, R. J., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media. Tissue Eng Part A 19, 1941-1948, PubMed.

Albro, M. B., Nims, R. J., Cigan, A. D., Yeroushalmi, K. J., Alliston, T., Hung, C. T., and Ateshian, G. A., 2013. Accumulation of exogenous activated TGF-beta in the superficial zone of articular cartilage. Biophys J 104, 1794-1804, PubMed.

Albro, M. B., Nims, R. J., Cigan, A. D., Yeroushalmi, K. J., Shim, J. J., Hung, C. T., and Ateshian, G. A., 2012. Dynamic mechanical compression of articular cartilage does not activate latent TGF-beta. J Biomech 46, 1433-1439, PubMed.

Albro, M. B., Cigan, A. D., Nims, R. J., Oungoulian, S. R., Hung, C. T., and Ateshian, G. A., 2012. Shearing of synovial fluid activates latent TGF-beta. Osteoarthritis Cartilage 20, 1374-1382, PubMed.

Zhang, Q., Cigan, A. D., Marraro, L., Lopreore, C., Liu, S., Ge, D., Savoie, F., and You, Z., 2011. Expression of doublecortin reveals articular chondrocyte lineage in mouse embryonic limbs. Genesis 49, 75-82.

Parekh, A., Cigan, A. D., Wognum, S., Heise, R., Chancellor, M., and Sacks, M. S., 2010. Ex vivo deformations of the urinary bladder wall during whole bladder filling: contributions of extracellular matrix and smooth muscle. J Biomech 43, 1708-1716.

Conference Abstracts

Ateshian, G. A., Nims, R. J., Cigan, A. D., and Hung, C. T., 2013. Theoretical and computational modeling of tissue growth mechanics with applications to quantitative cartilage tissue engineering. In: Biomedical Engineering Society Annual Meeting. Seattle, WA, USA.

Cigan, A. D., Nims, R. J., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Effects of media stirring and presence of nutrient channels on functional properties of large engineered cartilage constructs. In: ASME Summer Bioengineering Conference. Sunriver, OR, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Binding and release kinetics of glycosaminoglycans and collagen in engineered cartilage under TGF-beta supplementation. In: ASME Summer Bioengineering Conference. Sunriver, OR, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., Park, D. B., Vunjak-Novakovic, G., Hung, C. T., and Ateshian, G. A., 2013. Engineered cartilage supplemented with channels increases nutrient availability throughout large constructs: a finite element study. In: 11th International Symposium, Computer Methods in Biomechanics and Biomedical Engineering. Salt Lake City, UT, USA.

Albro, M. B., Nims, R. J., Cigan, A. D., Yeroushalmi, K. J., Shim, J. J., Chen, Y. B. C., Hung, C. T., and Ateshian, G. A., 2013. Dynamic mechanical compression of articular cartilage does not activate latent TGF-beta. In: 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, USA.

Cigan, A. D., Nims, R. J., Albro, M. B., Quien, M. M., Vunjak-Novakovic, G., Hung, C. T., and Ateshian, G. A., 2013. Identification of a glucose concentration threshold critical for tissue growth in engineered cartilage. In: 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., O'Connell, G. D., Park, D. B., Hung, C. T., and Ateshian, G. A., 2013. Frequent chondroitinase treatment in engineered cartilage with native level of cell seeding density does not enhance collagen deposition and is detrimental to chondrocytes. In: 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, USA.

Cigan, A. D., Nims, R. J., Albro, M. B., Breves, S. L., Hung, C. T., and Ateshian, G. A., 2012. Insulin and ascorbate have a much greater influence than transferrin and selenous acid on the growth of engineered cartilage in chondrogenic media. In: ASME Summer Bioengineering Conference. Fajardo, PR, USA.

Ateshian, G. A., Nims, R. J., Cigan, A. D., Albro, M. B., and Hung, C. T., 2012. Finite element modeling of matrix synthesis and binding kinetics in a biphasic-solute material. In: ASME Summer Bioengineering Conference. Fajardo, PR, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., Wood, K. C., Hung, C. T., and Ateshian, G. A., 2012. Engineered cartilage constructs retain a much greater fraction of synthesized GAG and collagen than COMP. In: 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, USA.

Albro, M. B., Cigan, A. D., Nims, R. J., Chen, Y. B. C., Hung, C. T., and Ateshian, G. A., 2012. Synthesis and incorporation of latent TGF-beta into the extracellular matrix of engineered cartilage constructs. In: 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, USA.

Albro, M. B., Nims, R. J., Cigan, A. D., Chen, Y. B. C., Hung, C. T., and Ateshian, G. A., 2012. Accumulation of exogenous active TGF-beta in the superficial zone of immature bovine articular cartilage. In: 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, USA.

Wong, B. L., Cigan, A. D., Kim, S. H., and Sah, R. L., 2009. The effect of a focal articular defect on cartilage deformation during articulation. In: 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV, USA.

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