Robert J. Nims

Ph.D. 2017
Mudd Building, Room 134A
212-854-4259

Research Interests

  • Nutrient transport in tissue engineering
  • Growth and remodeling

 

Education

  • B.S. Boston University, Biomedical Engineering, May 2010
  • M.S. Columbia University, Biomedical Engineering, February 2012

Bob joined the MBL in the fall of 2010 working to formulate and validate computational models which describe the growth and development of engineered cartilage. Ultimately, the goal is to develop experimentally informed models to predict the compositional and mechanical properties of engineered tissues based on the prevailing culture conditions (construct geometry, cell density, nutrient supply).

When not enhancing the nutrient availability in engineered cartilage, Bob enhances the nutrient availability in his vegetable gardens.

Nims, R. J., Cigan, A. D., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels. J Biomech, PubMed.

Cigan, A. D., Nims, R. J., Albro, M. B., Esau, J. D., Dreyer, M. P., Vunjak-Novakovic, G., Hung, C. T., and Ateshian, G. A., 2013. Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media. Tissue Eng Part A 19, 1941-1948, PMCID: PMC3725793, PubMed.

Albro, M. B., Nims, R. J., Cigan, A. D., Yeroushalmi, K. J., Shim, J. J., Hung, C. T., and Ateshian, G. A., 2013. Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-beta. J Biomech 46, 1433-1439, PMCID: PMC3810401, PubMed.

Albro, M. B., Nims, R. J., Cigan, A. D., Yeroushalmi, K. J., Alliston, T., Hung, C. T., and Ateshian, G. A., 2013. Accumulation of exogenous activated TGF-beta in the superficial zone of articular cartilage. Biophys J 104, 1794-1804, PMCID: PMC3627867, PubMed.

Albro, M. B., Cigan, A. D., Nims, R. J., Yeroushalmi, K. J., Oungoulian, S. R., Hung, C. T., and Ateshian, G. A., 2012. Shearing of synovial fluid activates latent TGF-beta. Osteoarthritis Cartilage 20, 1374-1382, PMCID: PMC3448789, PubMed.

Conference Abstracts

Ateshian, G. A., Nims, R. J., Cigan, A. D., and Hung, C. T., 2013. Theoretical and computational modeling of tissue growth mechanics with applications to quantitative cartilage tissue engineering. In: Biomedical Engineering Society Annual Meeting. Seattle, WA, USA.

Cigan, A. D., Nims, R. J., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Effects of media stirring and presence of nutrient channels on functional properties of large engineered cartilage constructs. In: ASME Summer Bioengineering Conference. Sunriver, OR, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., Hung, C. T., and Ateshian, G. A., 2013. Binding and release kinetics of glycosaminoglycans and collagen in engineered cartilage under TGF-beta supplementation. In: ASME Summer Bioengineering Conference. Sunriver, OR, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., Park, D. B., Vunjak-Novakovic, G., Hung, C. T., and Ateshian, G. A., 2013. Engineered cartilage supplemented with channels increases nutrient availability throughout large constructs: a finite element study. In: 11th International Symposium, Computer Methods in Biomechanics and Biomedical Engineering. Salt Lake City, UT, USA.

Albro, M. B., Nims, R. J., Cigan, A. D., Yeroushalmi, K. J., Shim, J. J., Chen, Y. B. C., Hung, C. T., and Ateshian, G. A., 2013. Dynamic mechanical compression of articular cartilage does not activate latent TGF-beta. In: 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, USA.

Cigan, A. D., Nims, R. J., Albro, M. B., Quien, M. M., Vunjak-Novakovic, G., Hung, C. T., and Ateshian, G. A., 2013. Identification of a glucose concentration threshold critical for tissue growth in engineered cartilage. In: 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., O'Connell, G. D., Park, D. B., Hung, C. T., and Ateshian, G. A., 2013. Frequent chondroitinase treatment in engineered cartilage with native level of cell seeding density does not enhance collagen deposition and is detrimental to chondrocytes. In: 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, USA.

Cigan, A. D., Nims, R. J., Albro, M. B., Breves, S. L., Hung, C. T., and Ateshian, G. A., 2012. Insulin and ascorbate have a much greater influence than transferrin and selenous acid on the growth of engineered cartilage in chondrogenic media. In: ASME Summer Bioengineering Conference. Fajardo, PR, USA.

Ateshian, G. A., Nims, R. J., Cigan, A. D., Albro, M. B., and Hung, C. T., 2012. Finite element modeling of matrix synthesis and binding kinetics in a biphasic-solute material. In: ASME Summer Bioengineering Conference. Fajardo, PR, USA.

Nims, R. J., Cigan, A. D., Albro, M. B., Wood, K. C., Hung, C. T., and Ateshian, G. A., 2012. Engineered cartilage constructs retain a much greater fraction of synthesized GAG and collagen than COMP. In: 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, USA.

Albro, M. B., Cigan, A. D., Nims, R. J., Chen, Y. B. C., Hung, C. T., and Ateshian, G. A., 2012. Synthesis and incorporation of latent TGF-beta into the extracellular matrix of engineered cartilage constructs. In: 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, USA.

Albro, M. B., Nims, R. J., Cigan, A. D., Chen, Y. B. C., Hung, C. T., and Ateshian, G. A., 2012. Accumulation of exogenous active TGF-beta in the superficial zone of immature bovine articular cartilage. In: 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, USA.

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