Nadeen O. Chahine

Current Position

Associate Professor of Biomechanics (in Orthopaedic Surgery), Dept of Orthopaedic Surgery, Columbia University

Research Interests

  • Cartilage mechanics
  • Cartilage tissue engineering

Education

  • B.S. Boston University, Biomedical Engineering, 2000
  • M.S. Columbia University, Biomedical Engineering, 2002
  • M.Phil. Columbia University, Biomedical Engineering, 2006
  • Ph.D. Columbia University, Biomedical Engineering, 2006

Nadeen's Ph.D. co-sponsors were Profs. Gerard Ateshian and Clark Hung.  After completing her Ph.D. at Columbia, Nadeen did a postdoc fellowship at the Lawrence Livermore National Laboratory.  She subsequently took a faculty position at the Feinstein Institute for Medical Research in New York.  She is currently Associate Professor of Biomechanics in the Department of Orthopaedic Surgery at Columbia.

Publications

Stefani, R. M., Halder, S. S., Estell, E. G., Lee, A. J., Silverstein, A. M., Sobczak, E., Chahine, N. O., Ateshian, G. A., Shah, R. P., and Hung, C. T., 2019. A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment. Tissue Eng Part A 25, 538-553, PMCID: PMC6482911, PubMed.

O'Connell, G. D., Lima, E. G., Bian, L., Chahine, N. O., Albro, M. B., Cook, J. L., Ateshian, G. A., and Hung, C. T., 2012. Toward engineering a biological joint replacement. J Knee Surg 25, 187-196, PMCID: PMC3700804, PubMed.

Chahine, N. O., Albro, M. B., Lima, E. G., Wei, V. I., Dubois, C. R., Hung, C. T., and Ateshian, G. A., 2009. Effect of dynamic loading on the transport of solutes into agarose hydrogels. Biophys J 97, 968-975, PMCID: PMC2726307, PubMed.

Ateshian, G. A., Rajan, V., Chahine, N. O., Canal, C. E., and Hung, C. T., 2009. Modeling the matrix of articular cartilage using a continuous fiber angular distribution predicts many observed phenomena. J Biomech Eng 131, 061003, PMCID: PMC2842192, PubMed.

Moffat, K. L., Sun, W. H., Pena, P. E., Chahine, N. O., Doty, S. B., Ateshian, G. A., Hung, C. T., and Lu, H. H., 2008. Characterization of the structure-function relationship at the ligament-to-bone interface. Proc Natl Acad Sci U S A 105, 7947-7952, PMCID: PMC2430342, PubMed.

Albro, M. B., Chahine, N. O., Li, R., Yeager, K., Hung, C. T., and Ateshian, G. A., 2008. Dynamic loading of deformable porous media can induce active solute transport. J Biomech 41, 3152-3157, PMCID: PMC2633098, PubMed.

Chahine, N. O., Hung, C. T., and Ateshian, G. A., 2007. In-situ measurements of chondrocyte deformation under transient loading. Eur Cell Mater 13, 100-111; discussion 111, PubMed.

Chahine, N. O., Ateshian, G. A., and Hung, C. T., 2007. The effect of finite compressive strain on chondrocyte viability in statically loaded bovine articular cartilage. Biomech Model Mechanobiol 6, 103-111, PubMed.

Basalo, I. M., Chahine, N. O., Kaplun, M., Chen, F. H., Hung, C. T., and Ateshian, G. A., 2007. Chondroitin sulfate reduces the friction coefficient of articular cartilage. J Biomech 40, 1847-1854, PubMed.

Albro, M. B., Chahine, N. O., Caligaris, M., Wei, V. I., Likhitpanichkul, M., Ng, K. W., Hung, C. T., and Ateshian, G. A., 2007. Osmotic loading of spherical gels: a biomimetic study of hindered transport in the cell protoplasm. J Biomech Eng 129, 503-510, PMCID: PMC2828939, PubMed.

Moffat, K. L., Sun, W. H., Chahine, N. O., Pena, P. E., Doty, S. B., Hung, C. T., Ateshian, G. A., and Lu, H. H., 2006. Characterization of the mechanical properties and mineral distribution of the anterior cruciate ligament-to-bone insertion site. Conf Proc IEEE Eng Med Biol Soc 2006, 2366-2369, PubMed.

Ng, K. W., Wang, C. C., Mauck, R. L., Kelly, T. A., Chahine, N. O., Costa, K. D., Ateshian, G. A., and Hung, C. T., 2005. A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. J Orthop Res 23, 134-141, PubMed.

Chahine, N. O., Chen, F. H., Hung, C. T., and Ateshian, G. A., 2005. Direct measurement of osmotic pressure of glycosaminoglycan solutions by membrane osmometry at room temperature. Biophys J 89, 1543-1550, PMCID: PMC1366659, PubMed.

Chahine, N. O., Wang, C. C., Hung, C. T., and Ateshian, G. A., 2004. Anisotropic strain-dependent material properties of bovine articular cartilage in the transitional range from tension to compression. J Biomech 37, 1251-1261, PMCID: PMC2819725, PubMed.

Ateshian, G. A., Chahine, N. O., Basalo, I. M., and Hung, C. T., 2004. The correspondence between equilibrium biphasic and triphasic material properties in mixture models of articular cartilage. J Biomech 37, 391-400, PMCID: PMC2819758, PubMed.

Wang, C. C., Chahine, N. O., Hung, C. T., and Ateshian, G. A., 2003. Optical determination of anisotropic material properties of bovine articular cartilage in compression. J Biomech 36, 339-353, PMCID: PMC2809654, PubMed.